Quentin (Nat Wolff) is a young and shy high school senior about to graduate. He has always played it safe and lives his life within a narrow comfort zone. Within a few weeks of graduation, he is in for a night of his life when Margo (Cara Delevingne), the most popular student at his high school and a girl he has known since childhood, enlists him to help her play pranks on some of her friends that have wronged her. The next day, she suddenly is missing. With the help of his two best friends Ben (Austin Abrams) and Radar (Justice Smith) and others, they try to decipher clues that she left behind, Quentin goes on a mission to find the girl who he has now fallen in love with and made him feel alive.